sive daytime sleepiness (EDS).^7,8 We are striving to harness the potential of orexin science, which regulates several critical biological functions including sleep/wakefulness, respiration and metabolism, to improve the care for individuals with rare sleep disorders and orexin-related conditions.^9,10,11 * **Neurodegeneration:** Neurodegenerative diseases are a major global health burden in our aging world.¹² We seek to change the treatment paradigm for neurodegenerative diseases including Alzheimer’s disease, frontotemporal dementia and multiple system atrophy by developing next generation therapies with meaningful outcomes beyond symptom management. * **Rare Neurology:** Rare neurological and neuromuscular disorders can have significant impacts, and the need for innovative therapies is immense.¹³ By leveraging our understanding of what causes these diseases, we can aim to develop disease-modifying therapies across a range of treatment approaches.31:T540,* **Rare Sleep Disorders and Orexin-related Conditions:** People living with narcolepsy and related sleep-wake disorders can suffer from debilitating symptoms that significantly impact their daily life.^5,6 Narcolepsy type 1 (NT1), narcolepsy type 2 (NT2), and idiopathic hypersomnia are rare disorders characterized by excessive daytime sleepiness (EDS).^7,8 We are striving to harness the potential of orexin science, which regulates several critical biological functions including sleep/wakefulness, respiration and metabolism, to improve the care for individuals with rare sleep disorders and orexin-related conditions.^9,10,11 * **Neurodegeneration:** Neurodegenerative diseases are a major global health burden in our aging world.¹² We seek to change the treatment paradigm for neurodegenerative diseases including Alzheimer’s disease, frontotemporal dementia and multiple system atrophy by developing next generation therapies with meaningful outcomes beyond symptom management.